The Rheological Properties of Lipid Monolayers Modulate the Incorporation of L-Ascorbic Acid Alkyl Esters

YENISLEIDY DE LAS MERCEDES ZULUETA DIAZ; MILAGRO MOTTOLA; RAQUEL VIVIANA VICO; NATALIA WILKE; MARIA LAURA FANANI

AMER CHEMICAL SOC

Lugar: Washington; Año: 2016 vol. 32 p. 587 - 587

n this work we tested the hypothesis that the incorporation of amphiphilic drugs into lipid membranes may be regulated by their rheological properties. For this purpose two members of the L-ascorbic acid alkyl esters family (ASCn) were selected: ASC16 and ASC14, which have different rheological properties when organized at the air/water interface. They are lipophilic forms of vitamin C used in topical pharmacological preparations. The effect of the phase state of the host lipid membranes on ASCn incorporation was explored using Langmuir monolayers. Films of pure lipids with known phase states have been selected, showing liquid-expanded, liquid-condensed and solid phases as well as pure cholesterol films in liquid-ordered state. We also tested ternary and quaternary mixed films that mimic the properties of cholesterol containing membranes and of the stratum corneum. The compressibility and shear properties of those monolayers were assessed in order to define its phase character. We fou