Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (Jenynsia multidentata) exposed to these insecticides singly and in mixture.

BONANSEA, ROCÍO; MARINO, DAMIÁN J.; BERTRAND, LIDWINA; WUNDERLIN, DANIEL ALBERTO; AMÉ, MARÍA VALERIA

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

SETAC PRESS

Lugar: Buenos Aires; Año: 2016 vol. 36 p. 1764 - 1764

0730-7268

he aim of the present study was to evaluate the accumulation of cypermethrin (CYP) and chlorpyrifos (CPF) when the fish Jenynsia multidentata was exposed to these pesticides singly and in technical and commercial mixtures. Adult female fishes were exposed over 96 h to 0.04 µg/L of CYP; 0.4 µg/L of CPF; 0.04 µg/L CYP + 0.4 µg/L CPF in a technical mixture; and 0.04 µg/L CYP + 0.4 µg/L CPF in a mixture of commercial products. Fish exposed to CYP accumulated this compound only in muscle, probably due to low biotransformation capacity of this organ and to the induction of cytochrome P4501A1 (CYP1A1) expression in the liver. The accumulation of CPF occurred in fish exposed to the insecticide (intestine>liver>gills) even when these fishes had higher Gluthatione S-transferase activity in gills and P-glycoprotein (P-gp) expression in liver, compared with the control. Fish exposed to the technical mixture showed CYP accumulation (liver>intestine>gills) with higher levels than measured in fish a