Multiantibiotic Residues in Commercial Fish From Argentina. The Presence of Mixtures of Antibiotics in Edible Fish, a Challenge to Health Risk Assessment.

GRIBOFF, JULIETA; CARRIZO, JUAN CRUZ; BONANSEA, ROCÍO INÉS; VALDES, MARIA EUGENIA; WUNDERLIN, DANIEL ALBERTO; AMÉ, MARÍA VALERIA

FOOD CHEMISTRY

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2020 vol. 332

0308-8146

he occurrence of 46 antibiotics (amphenicols, cephalosporins, dihydrofolate reductase inhibitors, fluroquinolones, macrolides, nitrofurans, penicillins, quinolones, sulfamides and tetracyclines) in Argentinean market fish were investigated by UPLC-MS/MS. Veterinary and human antimicrobials enrofloxacin, clarithromycin, roxithromycin, doxycycline and oxytetracycline were detected in 100 % of the samples, being to our knowledge the first report of clarithromycin in edible fish muscle. Maximum Residual Limits were exceeded for at least one antibiotic in 82 % of pacú, 57 % of shad, 57 % of trout and 50 % of salmon samples. Chloramphenicol, furazolidone and nitrofurantoin (banned compounds in food items) were detected in 41 %, 22 % and 4 % of the samples, respectively. Based on the estimated daily intake calculation, samples do not pose a serious risk to public health. Further investigation on the chronic impact and risk calculation of the mixture of antibiotics on the aquatic environment