In vitro activity ofN-benzenesulfonylbenzotriazole on Trypanosoma cruzi epimastigote and trypomastigote forms

BECERRA M C; GUIÑAZÚ, N.; HERGERT LY; PELLEGRINI A; MAZZIERI M R; GEA S; ALBESA I

ACADEMIC PRESS INC ELSEVIER SCIENCE

Año: 2012 vol. 131 p. 57 - 57

font size="1" face="AdvGulliv-R"> Chagas disease is still an important health problem in Central and South America. However, the only drugs currently available for specific treatment of this disease may induce toxic side effects in the host. The aim of this work was to determine the activity of N-benzenesulfonylbenzotriazole (BSBZT) against the protozoan parasite Trypanosoma cruzi. The effects of BSBZT and benzotriazole (BZT) were compared to those of Benznidazole (BZL) on epimastigote and trypomastigote forms. BSBZT was found to have an in vitro growth inhibitory dose-dependent activity against epimastigotes, with flow cytometry