BECERRA MARIA CECILIA
Artículos
Título:
Induction of NADPH oxidase activity and reactive oxygen species production by a single Trypanosoma cruzi antigen
Autor/es:
GUIÑAZU N; CARRERA SILVA E; BECERRA MC; PELLEGRINI A; ALBESA I; GEA S
Editorial:
ELSEVIER SCI LTD
Referencias:
Año: 2010 vol. 40 p. 1531 - 1531
Resumen:
font size="1" face="AdvGulliv-I"> Trypanosoma cruzi is an intracellular protozoan parasite that predominantly invades mononuclear phagocytes and is able to establish a persistent infection. The production of reactive oxygen species (ROS) by phagocytes is an innate defence mechanism against microorganisms. It has been postulated that ROS such as superoxide anion (O2), hydrogen peroxide and peroxynitrite, may play a crucial role in the control of pathogen growth. However, information on parasite molecules able to trigger ROS production is scarce. In this work, we investigated whether cruzipain, an immunogenic glycoprotein from T