Lipids and DNA Oxidation in Staphylococcus aureus as a consequence of oxidative stress generated by ciprofloxacin

BECERRA, M. C.; PÁEZ PL; LARÓVERE, L. E.; ALBESA, I

Kluwer Academic

Año: 2006 vol. 285 p. 29 - 29

font size="3" face="TimesNewRoman"> Ciprofloxacin induced an increment of reactive oxygen species in sensitive strains of Staphylococcus aureus leading to oxidative stress detected by chemiluminescence  while resistant strains did not suffer such stress. Oxidation of lipids was performed by employing thiobarbituric acid reaction to detect the formation of an amplified intermediate between reactive species oxygen  and cytoplasmic macromolecules, namely malondialdehyde (MDA). The sensitive strain presented higher peroxidation of lipids than the resistant strain. The