AT 1 ‐R is involved in the development of long‐lasting, region‐dependent and oxidative stress‐independent astrocyte morphological alterations induced by Ketamine

OCCHIEPPO, VICTORIA B.; BASMADJIAN, OSVALDO M.; MARCHESE, NATALIA A.; SILVERO, M.C. JAZMIN; RODRÍGUEZ, ANAHÍ; ARMONELLI, SAMANTA; BECERRA, M. CECILIA; BAIARDI, GUSTAVO; BREGONZIO, CLAUDIA

EUROPEAN JOURNAL OF NEUROSCIENCE

WILEY-BLACKWELL PUBLISHING, INC

Año: 2020

0953-816X

strocytes play an essential role in the genesis, maturation and regulation of the neurovascular unit. Multiple evidence support that astrocyte reactivity has a close relationshipto neurovascular unit dysfunction, oxidative stress and inflammation, providing a suitable scenario for the development of mental disorders. Ketamine has been proposed as a single‐use antidepressant treatment in major depression and its antidepressant effects have been associated with anti‐inflammatory properties. However, Ketamine long‐lasting effects over the neurovascular unit components remain unclear. Angiotensin II AT1 receptor (AT1‐R) blockers have anti‐inflammatory, antioxidant and neuroprotective effects. The present work aims to distinguish the acute and long‐term Ketamine effects over astrocytes response extended to other neurovascular unit components, and the involvement of AT1‐R, in prefrontal cortex and ventral tegmental area. Male Wistar rats were admini