Integrating chemical and biological data by chemometrics to evaluate detoxification responses of a neotropical bivalve to metal and metalloid contamination

SOUZA, IARA DA C.; MOROZESK, MARIANA; AZEVEDO, VINICIUS C.; GRIBOFF, JULIETA; ELLIOTT, MICHAEL; MATSUMOTO, SILVIA T.; MONFERRÁN, MAGDALENA V.; WUNDERLIN, DANIEL A.; FERNANDES, MARISA N.

CHEMOSPHERE

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2023 vol. 340

0045-6535

angroves represent a challenge in monitoring studies due to their physical and chemical conditions under constant marine and anthropogenic influences. This study investigated metals/metalloids whole-body bioaccumulation (soft tissues) and the risk associated with their uptake, biochemical and morphological detoxification processes in gills and metals/metalloids immobilisation in shells of the neotropical sentinel oyster Crassostrea rhizophorae from two Brazilian estuarine sites. Biochemical and morphological responses indicated three main mechanisms: (1) catalase, superoxide dismutase and glutathione played important roles as the first defence against reactive oxygen species; (2) antioxidant capacity against peroxyl radicals, glutathione S-transferase, metallothionein prevent protein damage and (3) metals/metalloids sequestration into oyster shells as a mechanism of oyster detoxification. However, the estimated daily intake, target hazard quotient, and hazard index showed that the hum