Altered Serum IgG Levels to alpha-Synuclein in Dementia with Lewy Bodies and Alzheimer’s Disease

KOEHLER N; STRANSKY E; SHING M; GAERTNER S; MEYER M; SCHREITMUELLER B; LEYHE T; LASKE C; MAETZLER W; KAHLE P; CELEJ MS; JOVIN TM; FALLGATTER A; BATRA A; BUCHKREMER G; SCHOTT K; RICHARTZ-SALZBURGER E

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2013 vol. 8 p. 64649 - 64649

atural self-reactive antibodies in the peripheral blood may play a considerable role in the control of potentially toxic proteins that may otherwise accumulate in the aging brain. The significance of serum antibodies reactive against asynuclein is not well known. We explored serum IgG levels to monomeric a-synuclein in dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) with a novel and validated highly sensitive ELISA assay. Antibody levels revealed stark differences in patients compared to healthy subjects and were dependent on diagnosis, disease duration and age. Anti-asynuclein IgG levels were increased in both patient groups, but in early DLB to a much greater extent than in AD. Increased antibody levels were most evident in younger patients, while with advanced age relatively low levels were observed, similar to healthy individuals, exhibiting stable antibody levels independent of age. Our data show the presence of differentially altered IgG levels against a-synuclein i