Growth hormone treatment in childrenwith idiopathic short stature: correlation of growth responsewith peripheral thyroid hormone action

SUSPERREGUY S; MUÑOZ L; TKALENKO NY; MASCANFRONI ID; ALAMINO VA; MONTESINOS, MM; MASINI-REPISO AM; MIRAS MB; PELLIZAS CG

WILEY-BLACKWELL PUBLISHING, INC

Año: 2011 vol. 74 p. 346 - 346

bjective Idiopathic short stature (ISS) describes short childrenwith normal GH secretion. Although GH treatment increases theirheights, growth response to the therapy differs among patients.Thyroid hormones (TH) are essential for longitudinal growth act-ingmainly through TH receptors (TR) a and b.We have previouslyreported that GH treatment reduced peripheral TH action inTurner Syndrome by TR down-regulation. The aims of the studywere to assess the effect of GH treatment to ISS on peripheral THaction and the correlation between thyroid status and growthresponse to the therapy.Subjects, design and measurements Eighteen normal (con-trol) and twenty-five ISS children were enrolled and evaluatedbefore and after 12 months of life time (control) or 12 months ofGH therapy (ISS). Fasting blood was used for serum biochemicalevaluations, peripheral blood mononuclear cells for TR mRNAdetermination by