Control of dendritic cell maturation and function by triiodothyronine

MASCANFRONI ID1, MONTESINOS MM1; SUSPERREGUY S; CERVI L; ILARREGUI JM; RAMSEYER VD; MASINI-REPISO AM; TARGOVNIK HM; RABINOVICH GA; PELLIZAS CG. 1-ESTOS AUTORES CONTRIBUYERON DE IGUAL MANERA AL TRABAJO Y DEBEN SER CONSIDERADOS COMO PRIMEROS AUTORES.

FASEB JOURNAL

FEDERATION AMER SOC EXP BIOL

Lugar: Bethesda; Año: 2008 vol. 22 p. 1032 - 1032

0892-6638

b> Accumulating evidence indicates a functional  crosstalk between immune and endocrine mechanisms  in the modulation of innate and adaptive immunity.  However, the impact of thyroid hormones (THs)  in the initiation of adaptive immune responses has not  yet been examined. Here we investigated the presence  of thyroid hormone receptors (TRs) and the impact of  THs in the physiology of mouse dendritic cells (DCs),  specialized antigen-presenting cells with the unique  capacity to fully activate naive T cells and orchestrate  adaptive immunity. Both immature and lipopolysaccharide-  matured bone marrow-derived DCs expressed TRs  at mRNA an