Editorial: Thyroid hormone actions in cancer

CAYROL, FLORENCIA; STERLE, HELENA ANDREA; MONTESINOS, MARIA DEL MAR

Frontiers in Endocrinology

Frontiers Media S.A.

Año: 2023 vol. 14 p. 1 - 1

hyroid hormones (THs) are well known for being key players in controlling cellmetabolism, growth, and many other important physiological processes such as embryonicdevelopment and cell differentiation (1). THs exert their biological actions primarilythrough the binding of 3,5,3′-triiodo-l-thyronine (T3) to its nuclear receptor TR thatsubsequently homodimerizes (TR/TR) and/or heterodimerizes with retinoid X receptor –RXR- (TR/RXR) to regulate the transcription of target genes containing a TH-responseelement (TRE). Circulating TH levels are largely stable, in humans approximately 80% ofserum T3 is derived from T4 by the iodothyronine deiodinases that are expressed in atissue-specific manner in fetal and adult life. Importantly, deiodinase-mediatedmechanisms within target cells can modulate TH signaling (2). In addition, it wasdescribed that both, T3 and T4 (l-thyroxine), activate membrane-bound receptors suchas the integrin avb3 triggering different signaling pathways that ultimat