Thyroid cancer multicenter study in adult population of Cordoba (Argentina): A retrospective (1999-2019) 20-years study

ORTIZ, GUSTAVO; GERES, A; BERGOGLIO, L; LOPEZ, M; CASTRO, R; CLARIÁ, M; CUVERTINO, E; DAMILANO, R; FERRARIS, D; GELMANN, L; MONTESINOS MM; MORENO, P; RAMACCIOTTI, C; RUGGERI, M; SUAREZ, S; VALDUVINO, C

Virtual

Congreso; 19th International Congress of Endocrinology; 2021

Sociedad Internacional de Endocrinología

Introduction: The incidence of thyroid cancer (DTC): true or due to diagnostic improvement is on the rise. STUDY DESIGN: Retrospective analysis.Objectives: To evaluate the prevalence and variables associated with response to treatment in Province of Cordoba (Argentina).Methods: Data of contributing Centers in public and private settings. Outcomes of interest were sex prevalence , trend in rural areas with environmental toxics, and Hashimoto’s thyroiditis (HT) as a risk factor.Results: Total patients were 369 : 27% from Public and 73% from Private Centers, 58% from urban and 42% from rural areas. Female (F) / Male (M) ratio : 4.5. Mean±SD age at diagnosis (AD): 46 ± 13years. Predominant histological type: papillary (96.2%). The prevalence (P) was 10.45 and 34.5 cases per year between 1999 -2012 and between 2013 – 2019 respectively with an increase in microcarcinomas in the last years. A higher % of cases was observed in M, both in fumigated areas (FA) vs. no fumigated areas (NFA): (M 8% vs. F 6% and M 13% vs F 3% respectively), (p: 0.006). thesame as a higher percentage of broad capsular invasion (M 23% vs. F11% and M 5% vs. F 3%) respectively. p: 0,040.Recurrence risk (RR) was higher in both Men and Women in FA vs. NFA (M 23% vs. 6% and F 11% vs. 5% ) respectively. AD was different in FA vs. NFA: 35-39 vs 50 -54 years respectively (p: 0.0001). Diabetics showed a higher P compared to non-diabetics, (39% vs. 29%) p: 0.001) ,: The influence of autoimmunity (on tumor aggressiveness and response to treatment showed that positive TgAb patients (+TgAb) had more extensive lymphovascular invasion compared to negative TgAb pt (- TgAb). OR : 14.83 (95% CI: 3.21 - 68.41). Also, + TgAb had a higher RR (OR : 3.01 (95% CI: 1.10 - 8.23) and P (OR : 2.62 (95% CI: 1.36 - 5.04) compared to (-TgAb); + TPOAb patients had 70% ofexcellent response vs. 30% of -TPOAb p: 0.0008.Conclusion: Data were established for DTC trend in Province of Cordoba (Argentina). There are an heterogeneous incidence across different areas, increased and at earlier age in rural areas with environmental toxics. Size and tumor aggressiveness were higher in males than in women. + TgAb should be regarded as a risk condition for an active search for R or P disease. Until the association HT and DTC is clarified, patients with HT should monitored periodically forunderlying thyroid malignancy.