Membrane-peptide interaction: Focusing on membrane properties

MONTI MARIELA R.

Science Reviews - from the end of the world

Science Reviews - from the end of the world

Año: 2023

2683-9288

ellular membranes compartmentalize cells, comprise a permeability barrier, and are the starting place for several signaling cascades and processes in which lateral diffusion of molecules is a key factor. Although it has been shown that organisms adapt the lipid composition of their membranes in order to maintain these in a mainly fluid state, several studies point to the coexistence of regions with different compositions and mechanical properties. In this context, while proteins have been related to solid docks, sterols are accepted as liquid-ordered phase state inducers. Thus, the current model for membranes is a patchwork-like surface, with the different regions being highly variable in size and very dynamic.Many peptides, like cationic antimicrobial peptides and cell penetrating peptides, target cell membranes. The affinity of these soluble peptides to membranes depends on membrane features such as composition, charge density, compaction, and fluidity. As a consequence of the patch