AHUMADA MARIA INES
Artículos
Título:
New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide
Revista:
Bentham Science
Editorial:
School of Pharmacy Queen's University Belfast
Referencias:
Lugar: Belfast; Año: 2014 vol. 8 p. 224 - 224
ISSN:
1872-2113
Resumen:
his article reports the results concerning the design and manufacture of a novel polymeric film for ocular administration of acetazolamide (AZM), and a patent document presented to INPI- National Institute of Industrial/Intelectual Property. The system was designed using mucoadhesive polymers, such as carbomer (CB974P) and sodium carboxymethylcellulose (NaCMC), combined with the poloxamer (POL407) which behaves as a swelling modulator, surfactant and slightly plasticizer. The maximum amount of AZM to be incorporated without loss of homogeneity or precipitation of the drug, was 0.04 mg AZM/mg of the film. The addition of a polymeric coating based on Eudragit RSPO (cationic permeable polymethacrylate polymer) allowed optimizing drug release. The coating in a proportion of 10% (determined as percentage of total weight of the film) seemed to be the most adequate, since 80% of controlled drug release was achieved along 240 minutes. This coating membrane did not affect the mucoadhesive prop