Urban propolis from San Juan province (Argentina):Ethnopharmacological uses and antifungal activity against Candidaand dermatophytes

AGUERO, MARIA BELEN; SVETAZ LAURA; BARONI M.V.; LIMA BEATRIZ; LUNA LORENA; SUSANA ZACHINO; SAAVEDRA PEDRO; WUNDERLIN D. A.; FERESIN, G.E.; TAPIA, A.

Industrial Crops and Products

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2014 vol. 57 p. 166 - 166

0926-6690

ropolis is widely used in the folk medicine of San Juan province (Argentina) to treat several diseases,including cold, cough, muscle aches and superficial mycoses. We report the in vitro antifungal activity ofurban propolis, evaluated with CLSI protocols in addition to the evaluation of their chemical profile byHPLC-ESI-MS/MS techniques.The dermatophytes Microsporum gypseum, Trichophyton mentagrophytes and Trichophyton rubrum werethe most susceptible species and guided the fractionation of urban propolis, which was performed withSephadex LH-20 leading to eight fractions (I?VIII). These fractions showed high antifungal activitiesagainst dermatophytes (MICs = 16.0?62.5 g/mL) and yeasts (MICs = 31.2?125 g/mL) being III, V and VIthe most active ones (MIC100= 16?31.2 g/mL). They also, showed fungicidal capacity (a condition highlyappreciated in antifungal drugs to avoid recurrence) with MFC values between 31.2 and 62.5 g/mL.From the most active fractions, two lignans: 3-methyl-nordihydrogu