Cyclodextrin Multicomponent Complexes: Pharmaceutical Applications

AIASSA VIRGINIA; GARNERO CLAUDIA; LONGHI MARCELA; ZOPPI ARIANA

Pharmaceutics

MDPI

Año: 2021 vol. 13

1999-4923

yclodextrins (CDs) are naturally available water-soluble cyclic oligosaccharides widelyused as carriers in the pharmaceutical industry for their ability to modulate several properties ofdrugs through the formation of drug?CD complexes. The addition of an auxiliary substance whenforming multicomponent complexes is an adequate strategy to enhance complexation efficiency andto facilitate the therapeutic applicability of different drugs. This review discusses multicomponentcomplexation using amino acids; organic acids and bases; and water-soluble polymers as auxiliaryexcipients. Special attention is given to improved properties by including information on thesolubility, dissolution, permeation, stability and bioavailability of several relevant drugs. In addition,the use of multicomponent CD complexes to enhance therapeutic drug effects is summarized.