Cyclodextrins and Their Derivatives as Drug Stability Modifiers

AIASSA V

pharmaceuticals

Multidisciplinary Digital Publishing Institute (MDPI)

Año: 2023

1424-8247

yclodextrins (CDs) are cyclic oligosaccharides that contain a relatively hydrophobiccentral cavity and a hydrophilic outer surface. They are widely used to form non-covalent inclusioncomplexes with many substances. Although such inclusion complexes typically exhibit higheraqueous solubility and chemical stability than pure drugs, it has been shown that CDs can promotethe degradation of some drugs. This property of stabilizing certain drugs while destabilizing otherscan be explained by the type of CD used and the structure of the inclusion complex formed. Inaddition, the ability to form complexes of CDs can be improved through the addition of suitableauxiliary substances, forming multicomponent complexes. Therefore, it is important to evaluate theeffect that binary and multicomponent complexes have on the chemical and physical stability ofcomplexed drugs. The objective of this review is to summarize the studies on the stabilizing anddestabilizing effects of complexes with CDs on drugs