Tuning the Molecular Structure of Corroles to Enhance the Antibacterial Photosensitizing Activity

AIASSA V

Pharmaceutics

Multidisciplinary Digital Publishing Institute (MDPI)

Año: 2023

1999-4923

he increase in the antibiotic resistance of bacteria is a serious threat to public health. Photodynamic inactivation (PDI) of micro-organisms is a reliable antimicrobial therapy to treat a broad spectrum of complex infections. The development of new photosensitizers with suitable properties is a key factor to consider in the optimization of this therapy. In this sense, four corroleswere designed to study how the number of cationic centers can influence the efficacy of antibacterial photodynamic treatments. First, 5,10,15- ris(pentafluorophenyl)corrole (Co) and 5,15-bis(pentafluorophenyl)- 10-(4-(trifluoromethyl)phenyl)corrole (Co-CF3) were synthesized, and then derivatizedby nucleophilic aromatic substitution with 2-dimethylaminoethanol and 2-(dimethylamino) ethylamine, obtaining corroles Co-3NMe2 and Co-CF3-2NMe2, respectively. The straightforward synthetic strategy gave rise to macrocycles with different numbers of tertiary amines that can acquire positive charges in an aqueous medi