Innovative technological systems to optimize the delivery and therapeutic activity of antimicrobial drugs.

Advances and avenues in the development of novel carriers for bioactives and biological agents.

Academic Press of Elsevier

Lugar: London; Año: 2020; p. 105 - 140

A large number of active pharmaceutical ingredients (API) of therapeutic interest presents inappropriate physico-chemical properties (e.g. low dissolution rate, solubility, or permeability in biological fluids) that result in formulations with low bioavailability and large inter-subject variability producing therapeutic effectiveness related problems. Thus, one of the greatest challenges for the pharmaceutical field today is the application of technological formulation as strategies for improving permeability, solubility and dissolution performance of API to enhance their bioavailability. In recent years, various approaches have been developed to prepare drug delivery systems with advantageous and promising properties. This chapter focuses on the design of systems with improved properties based on the intermolecular interactions between the components, considering the formulation and manufacturing technics of the delivery systems as well as the factors that may affect the API and the pharmaceutical form. Specifically, the crucial role of the innovative systems, including binary and multicomponent complexes with cyclodextrins, solid self-emulsifying drug delivery systems, solid lipid nanoparticles and microemulsions will be describe. We will highlight the feasibility of these systems to improve biopharmaceutical properties (as solubility, dissolution rate and permeability), which are significantly different from those of the pure API form.