Peptide-Based Biomaterials Linking L-Tyrosine and Poly L-Tyrosine to Graphene Oxide Nanoribbons.

J. M. GONZáLEZ-DOMíNGUEZ; GUTIERREZ F.; J. HERNáNDEZ; A. ANSóN-CASAOS; RUBIANES M. D.,; G. A. RIVAS; MA. TERESA MARTINEZ

journal of chemistry materials B

RSC

Año: 2015 vol. 3 p. 3870 - 3870

2050-750X

p style="margin: 1em 0px 0pt;">Peptide-based biomaterials are actively being studied in a variety of applications in material science and biointerface engineering. Likewise, in the last decades, the potential biological applications of carbon nanomaterials, motivated by their size, shape, structure and their unique physical and chemical properties is being explored. In recent years, the functionalization of carbon nanotubes and graphene has led to the preparation of bioactive carbon nanomaterials that are being used in biomedicine as structural elements, in gene therapy and biosensing. In the present study, different strategies are given for the bonding of L-Tyrosine and the homopolypeptide Poly-L-Tyrosine (PTyr), to graphene oxide nanoribons (GONRs). Covalent attachment of L-Tyrosine was undertaken by amidation of the the á-amine group of tyrosine with the existing carboxylic groups in GONR an