Interleukins 1beta and 6 but not transforming growth factor-beta are critical cytokines for induction of human Th17 cells

ACOSTA RODRIGUEZ EV; NAPOLITANI G; LANZAVECCHIA A; SALLUSTO F

NATURE IMMUNOLOGY (PRINT)

Año: 2007 p. 942 - 942

1529-2908

font face="AdvTgb2" size="1"> Interleukin 17 (IL-17)?producing CD4+ helper T cells (TH-17 cells) have been linked to host defense and autoimmune diseases. In mice, the differentiation of TH-17 cells requires transforming growth factor-b and IL-6 and the transcription factor RORct. We report here that for human naive CD4+ T cells, RORct expression and TH-17 polarizat