Phenotypic and functional identification of human IL-17 producing memory T cells?

ACOSTA RODRIGUEZ EV; RIVINO L; GEGINAT J; JARROSSAY D; GATTORNO M; LANZAVECCHIA A; SALLUSTO F

NATURE IMMUNOLOGY (PRINT)

Año: 2007 p. 639 - 639

1529-2908

font face="AdvTgb2" size="1"> Interleukin 17 (IL-17)?producing T helper cells (TH-17 cells) have been characterized in mice as a distinct subset of effector cells, but their identity and properties in humans remain elusive. We report here that expression of CCR6 and CCR4 together identified human memory CD4+ T cells selectively producing IL-17 and expressing mRNA encoding the human ortholog of mouse RORct, a transcription factor, whereas CCR6 and CXCR3 identified TH1 cells producing interferon-c and T helper cells producing both interferon-