ACOSTA RODRÍGUEZ EVA VIRGINIA
Artículos
Título:
Galectin-3 Mediates Interleukin-4-Induced Survival and Differentiation of B Cells. Functional Cross-talk and Implications during Trypanosoma cruzi Infection
Autor/es:
ACOSTA RODRIGUEZ EV; ZUÑIGA EI; MONTES CL; MOTRAN CC; LIU FT; RABINOVICH GA; GRUPPI A
Revista:
JOURNAL OF IMMUNOLOGY
Referencias:
Año: 2004 p. 493 - 493
Resumen:
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The role of transcription factors in B cell survival and differentiation has been delineated during the last years. However, little is
known about the intermediate signals and the intracellular pathways that control these events. In this study, we provide evidence
both in vitro and in vivo, showing that galectin-3 (Gal-3), a -galactoside-binding protein, is a critical mediator of B cell differentiation
and survival. Although Gal-3 is not expressed in resting B cells from normal mice, its expression is markedly induced
after activation with stimuli such as IL-4 and CD40 cross-linking. These signals promote survival and block the final differentiation
of these cells, thus allowing the rising of a memory B cell phenotype. In addition, Gal-3 is