The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production

GOROSITO SERRÁN M; FIOCCA VERNENGO F; BECCARIA CG; ACOSTA RODRIGUEZ EV; MONTES CL; GRUPPI A

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2015 vol. 589 p. 3362 - 3362

he term regulatory B cells (B regs) is ascribed to a heterogeneous population of B cells with thefunction of suppressing inflammatory responses. They have been described mainly during the lastdecade in the context of different immune-mediated diseases. Most of the work on B regs has beenfocused on IL-10-producing B cells. However, B cells can exert regulatory functions independently ofIL-10 production. Here we discuss the phenotypes, development and effector mechanisms of B regsand advances in their role in autoimmunity, infections and cancer.