Trypanosoma cruzi trans-sialidase initiates an ROR-gt?AHR-independent program leading to IL-17 production by activated B cells

BERMEJO DA; JACKSON S; GOROSITO-SERRAN M; ACOSTA RODRIGUEZ EV; AMEZCUA VESELY MC; SATHER B; SINGH A; KHIM S; MUCCI J; LIGGITT D; CAMPETELLA O; OUKKA M; GRUPPI A; RAWLINGS D

NATURE PUBLISHING GROUP

Lugar: Londres; Año: 2013

e identified B cells as a major source for rapid, innate-like interleukin 17 (IL-17) production in vivo in response to Trypanosoma cruzi infection. IL-17+ B cells exhibited a plasmablast phenotype, outnumbered TH17 cells and were required for optimal response to this pathogen. Using both murine and human primary B cells, we demonstrate that exposure to parasite-derived trans-sialidase in vitro was sufficient to trigger modification of the cell surface mucin, CD45, leading to Btk-dependent signaling and IL-17A or F production via an ROR-t/AHR?independent transcriptional program. Our combined data suggest that generation of IL-17+ B cells may be an unappreciated feature of innate immune responses required for pathogen control or IL-17-mediated autoimmunity.