B cells from aged mice exhibit reduced apoptosis upon BCR stimulation and differential ability to up-regulate survival signals

MONTES CL; MALETTO BA; ACOSTA RODRIGUEZ EV; GRUPPI A; PISTORESI MC

CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Año: 2006 p. 30 - 30

0009-9104

b> During ageing, autoimmune disorders and the higher susceptibility to infectious have been associated with alterations in the humoral immune response. We report that splenic B lymphocytes from aged mice exhibit lower level of apoptosis induced by B-cell antigen receptor (BCR) ligation in vitro. Respect to B cells from young mice the anti-ì stimulated aged B cells show similar Bcl-2 and Bcl-xL expression but differential kinetic of A1 degradation and a higher level of cFLIP and FAIM. Even though B cells from aged mice show minor Fas expression they exhibit the same susceptibility to anti-Fas induced apoptosis. Aged B cells also present upon BCR stimulation, a higher proliferative response and similar level of activation markers expression than B cells f