Peritoneum from Trypanosoma cruzi infected mice is a homing site of Syndecan-1neg plasma cells which are main contributors of non-parasite specific antibodies.

MERINO MC; MONTES CL; ACOSTA RODRIGUEZ EV; BERMEJO DA; AMEZCUA VESELY MC; GRUPPI A

OXFORD UNIV PRESS

Año: 2010 vol. 22 p. 399 - 399

umoral immunity during experimental Chagas disease has been considered a double-edge sword, critical to control Trypanosoma cruzi spreading but also associated to tissue damage. Peritoneal B-1 cells have been linked to the pathogenesis of Chagas disease; however, they may also help to control the infection by providing a fast wave of antibodies. In the present work, we determined that peritoneal B-cell response to T. cruzi is characterized by a marked reduction of CD191 B cells due to plasma cell differentiation rather than to cell death. Both peritoneal B-2 and B-1 cells decrease after parasite infection, but with different kinetics. Thus, the reduction in B-2 cell number can be detected from day 4 postinfection while the number of B-1 cells decreases only after 15 days of infection. Differentiation of peritoneal B-1 and B-2 cells into IgM-secreting cells was triggered by parasites but not by cytokines produced by peritoneal cells. Electron microscopy studies showed that per