Role of Aryl Hydrocarbon Receptor (AhR) in the Regulation of Immunity and Immunopathology During Trypanosoma cruzi Infection

AMBROSIO L; INSFRAN C; VOLPINI X; ACOSTA RODRIGUEZ EV; SERRA H; QUINTANA F; CERVI LP; MOTRAN CC

FRONTIERS IN IMMUNOLOGY

Frontiers Media S.A.

Año: 2019

esistance to Trypanosoma cruzi infection is dependent on a rapid induction ofTh1-type and CD8+ T cell responses that should be promptly balanced to preventimmunopathology. T. cruzi-infected B6 mice are able to control parasite replicationbut show a limited expansion of Foxp3+regulatory T (Treg) cells that results in theaccumulation of effector immune cells and the development of acute liver pathology.AhR is a ligand-activated transcription factor that promotes Treg cell development andsuppression of pro-inflammatory cytokine production in dendritic cells, altering the courseof adaptive immune response and the development of immunopathology. Here, we useddifferent AhR-dependent activation strategies aiming to improve the Treg response, andB6 congenic mice carrying a mutant AhR variant with low affinity for its ligands (AhRd) toevaluate the role of AhR activation by natural ligands during experimental T. cruzi infection.The outcome of TCDD or 3-HK plus ITE treatments indicated that stro