Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli

PÁEZ PL; BAZAN C; BONGIOVANNI, MARIA EUGENIA; TONEATTO J; ALBESA I.; BECERRA M. C.; ARGÜELLO GA

BioMed Research International: Toxicology

Hindawi Publishing Corporation

Lugar: New York; Año: 2013 p. 1 - 1

2314-6133

he prevalence of antibiotic resistance has resulted in the need for new approaches to be developed to combat previously easily treatable infections. The main aim of this work was to establish the potential of the synthetic complexes like [Cr(phen)3]3+, [Cr(phen)2(dppz)]3+, [Ru(phen)3]2+ and [Ru(bpy)3]2+ as antibacterial agents by generating oxidative stress. The complex [Cr(phen)3]3+ and [Cr(phen)2(dppz)]3+ showed activity against Gram positive and Gram negative bacteria with minimum inhibitory concentrations (MICs) ranging from 0.125 µg/mL to 1 µg/mL, while [Ru(phen)3]2+ and [Ru(bpy)3]2+ did not show antimicrobial activity against the two bacterial genera studied. When ciprofloxacin was combined with [Cr(phen)3]3+ for the inhibition of S. aureus and E. coli, an important synergistic effect was observed, FIC 0.066 for S. aureus and FIC 0.064 for E. coli. The work described here shows that chromium(III) complexes are bactericidal for Staphylococcus aureus and Escherichia coli. Our resu