Targeted chitosan-based bionanocomposites for controlled oral mucosal delivery of chlorhexidine

ONNAINTY R,, .,, ; ONIDA B; PAEZ PL; LONGHI MR; BARRESI A; GRANERO G

INTERNATIONAL JOURNAL OF PHARMACEUTICS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 p. 408 - 408

0378-5173

he development of suitable antibacterial materials that could be utilized in the future for medical purposes still rates among the most current topics of medical research. Of particular interest are substances that can act as carriers of antibacterial or antimycotic agents for local treatment (e.g. of oral cavity infections) and thus to avoid treatment on the level of the entire organism in the first phase of the therapy. However, the relatively small surface area of the oral mucosa and the significant loss of drug due to uncontrolled swallowing and salivary flow are the main limitations of this route.1 The human buccal mucosa is multistratified, non-keranized and the drug permeation across the buccal epithelium is believed to involve both transcellular and paracellular routes. Despite the enormous efforts made in developing buccal drug delivery systems, only a few formulations have made a successful transition to the market