Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug

UGALDE-ARBIZU, MAIDER; AGUILERA-CORREA, JOHN JAIRO; GARCÍA-ALMODÓVAR, VICTORIA; OVEJERO-PAREDES, KARINA; DÍAZ-GARCÍA, DIANA; ESTEBAN, JAIME; PÁEZ, PAULINA L.; PRASHAR, SANJIV; SAN SEBASTIAN, EIDER; FILICE, MARCO; GÓMEZ-RUIZ, SANTIAGO

Pharmaceutics

MDPI

Año: 2023 vol. 15

ive different silica nanoparticles functionalized with vitamin B12, a derivative of coumarinfound in green plants and a minimum content of an organotin(IV) fragment (1-MSN-Sn, 2-MSNSn,2-SBA-Sn, 2-FSPm-Sn and 2-FSPs-Sn), were identified as excellent anticancer agents againsttriple negative breast cancer, one of the most diagnosed and aggressive cancerous tumors, withvery poor prognosis. Notably, compound 2-MSN-Sn shows selectivity for cancer cells and excellentluminescent properties detectable by imaging techniques once internalized. The same compound is also able to interact with and nearly eradicate biofilms of Staphylococcus aureus, the most common bacteria isolated from chronic wounds and burns, whose treatment is a clinical challenge. 2-MSN-Sn is efficiently internalized by bacteria in a biofilm state and destroys the latter through reactive oxygen species (ROS) generation. Its internalization by bacteria was also efficiently monitored by fluorescence imaging. Since silica nanopar