Maleamate-Functionalized Mesoporous Silica Nanoparticules with Multifunctional applications as Antibacterial Agents and Oxidation Catalysts

DÍAZ-GARCÍA D; ARDILES PR; PAEZ PL; PRASHAR S; GÓMEZ-RUIZ S

Granada

Congreso; I Congreso sobre Materiales Multifuncionales para Jóvenes ?MultiMat?; 2018

MultiMat

Mesoporous silica nanoparticles (MSN) are an interesting class of nanomaterials with potential applications in different areas such as the manufacture of nanodevices, catalysis and, especially, biomedicine [1,2]. Due to their small particle size, high surface area, easy functionalization and biocompatibility, MSN-based materials are extensively being used as drug carriers for antiinflammatory, analgesics, anticancer agents or in regenerative medicine [3]. However, its use as an antibacterial agent has still not been studied in depth. Therefore, the aim of this work is the synthesis of different functionalized nanostructured materials (such as MSN, SBA-15 or halloysite) containing a maleamato ligand (such as triethoxysilylpropylmaleamate) and the subsequent coordination of copper(II) ions for the exploration of their potential multifunctional applications both as antibacterial agents and as oxidation catalysts.Thus, the antibacterial effect of the supported copper(II) complexes has been tested against two types of bacteria (GRAM+ and GRAM-) in different assays to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Preliminary biological results show a good antibacterial activity against E. coli and S. aureus which has encouraged a more detailed study of the antibacterial mechanism of action of this kind of Cu-containing systems.Finally, the catalytic applications of these materials have been explored by testing them as catalysts in a ?solvent free? oxidation reaction of benzyl alcohol and other substrates with promising results.