New insights of brain renin-angiotensin system far beyond blood pressure: central angiotensin ii as a key modulator in the stress response and amphetamine induced-neuroadaptations

MARCHESE, NA; OCCHIEPPO,V; PAZ, MC; BAIARDI, G; BREGONZIO, C

Revista de Farmacologia de Chile

Sociedad de Farmacologia de Chile

Lugar: Valparaiso; Año: 2014 vol. 7 p. 17 - 17

0718-8811

ngiotensin II is known as a peripheral hormone involved in the control of blood pressure and fluids homeostasis. The study and characterization of angiotensin II and its receptors at the brain has opened a new vision of its physiological role and also offers a variety of research fields. Brain angiotensin II is a well-documented neuromodulator of multiple brain circuits. In this sense, angiotensin II is involved in the stress response and both, the brain and the peripheral (hormonal), angiotensin II systems are stimulated during stress. Activation of brain angiotensin II AT1 receptors is required for the stress-induced hormone secretion, including corticotropin-releasing hormone, adrenocorticotropic hormone, corticoids and vasopressin and for stimulation of the central sympathetic activity. The blockade of peripheral but also brain AT1 receptors prevents the hormonal and sympathoadrenal response to stress. Moreover, AT1 receptors activation is involved in natural reward responses and