Signatures of Adaptation to Obligate Biotrophy in the Hyaloperonospora arabidopsidis Genome

LAURA BAXTER; SUCHETA TRIPATHY; NAVEED ISHAQUE; NICO BOOT; ADRIANA CABRAL; ERIC KEMEN; MARCO THINES; AUDREY AH-FONG; RYAN ANDERSON; WOLE BADEJOKO; PETER BITTNER-EDDY; JEFFREY L. BOORE; MARCUS C. CHIBUCOS; MARY COATES; PARAMVIR DEHAL; KIM DELEHAUNTY; SUOMENG DONG; POLLY DOWNTON; BERNARD DUMAS; GEORGINA FABRO; CATRINA FRONICK; SUSAN I. FUERSTENBERG; LUCINDA FULTON; ELODIE GAULIN; FRANCINE GOVERS; LINDA HUGHES; SEAN HUMPHRAY; RAYS H. Y. JIANG; HOWARD JUDELSON; SOPHIEN KAMOUN; KIM KYUNG; HAROLD MEIJER; PATRICK MINX; PAUL MORRIS; JOANNE NELSON; VIPA PHUNTUMART; DINAH QUTOB; ANNE REHMANY; ALEJANDRA ROUGON-CARDOSO; PETER RYDEN; TRUDY TORTO-ALALIBO; DAVID STUDHOLME; YUANCHAO WANG; JOE WIN; JO WOOD; SANDRA W. CLIFTON; JANE ROGERS; GUIDO VAN DEN ACKERVEKEN; JONATHAN D. G. JONES; JOHN M. MCDOWELL; JIM BEYNON; BRETT M. TYLER

AMER ASSOC ADVANCEMENT SCIENCE

Lugar: Washington DC, USA; Año: 2010 vol. 330 p. 1549 - 1549

any oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrientsonly from living plant tissue and cannot grow apart from their hosts. Although these pathogenscause substantial crop losses, little is known about the molecular basis or evolution of obligatebiotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis(Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomesof related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions ingenes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes forassimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation andmotility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.