Interleukin-17 (IL-17)-mediated immunity controls skin infection and T helper 1 response during experimental Microsporum canis dermatophytosis

BURSTEIN, V.L.; GUASCONI, L.; BECCACECE, I.; THEUMER, M.G.; MENA, C.; PRINZ, I.; CERVI, L.; HERRERO, M.; MASIH, D.T.; CHIAPELLO, L.S.

JOURNAL OF INVESTIGATIVE DERMATOLOGY

NATURE PUBLISHING GROUP

Año: 2018

0022-202X

style type="text/css">p { margin-bottom: 0.25cm; line-height: 120%; }Despite worldwideprevalence of superficial mycoses, the immune response indermatophytosis has scarcely been investigated. In this study, wedeveloped a model of superficial skin infection in C57BL/6 mice withMicrosporum canis, a highly prevalent human pathogen. This modelmimics mild inflammatory human dermatophytosis, characterized byneutrophil recruitment and fungal invasion limited to the epidermis,and exhibits the establishment of a specific T helper 17 (Th17)immune response during infection. By using IL-17RA or IL-17A/Fdeficient mice we showed that, in the absence of a functional IL-17pathway, M. canis extensively colonizes the epidermis and promotes anexaggerated skin inflammation and a shift to an IFN-γ-mediated (Th1)response. Strikingly, IL-17 signaling was not involved in neutrophilinflux to skin or fungal invasion to deeper tissues. Finally, thiss