Tissue-specific IL-17-mediated immunity in experimental dermatophytosis

BURSTEIN VL; BECCACECE I; GUASCONI L; MENA C; MASIH DT; THEUMER MG; PRINZ I; GRUPPI A; CERVI L; CHIAPELLO LS

Congreso; International Congress of International Society of Human and Animal Mycology (ISHAM) and Infecciones Fúngicas en la Práctica Clínica de Latino América (INFOCUS); 2019

Despite the intimate contact we have with dermatophytes, little is known about how our immune system protects us from these pathogens and how pathogenic fungi drive skin immune homeostasis. Most studies that analyse antifungal immunity used generic populations of myeloid cells to better understand the mechanisms of fungal growth control.However, it is clear that our immune system exhibits organ-specific restrictions. This study directly explores the skin-specific antifungal immunity in vivo and monitors the dynamics of cutaneous T cell populations necessary for protection and homeostasis.To investigate the cell-mediated immunity involved in the skin antifungal response and the regulatory mechanisms that control inflammation during an experimental epicutaneous infection model with Microsporum canis in mice.Our investigations are the first that directly demonstrate the role of IL-17-mediated immunity in dermatophytosis in vivo and paves the way tofurther dissect tissue-specific immunity that deals with fungal pathogens