N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus

VALLEJO, M.G.; ORTEGA, M.G.; CABRERA, J.L.; AGNESE, A.M.

TETRAHEDRON LETTERS

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2013 vol. 54 p. 5197 - 5197

0040-4039

he present study describes the isolation and identification of N-demethyl-sauroxine, a novel Lycopodium alkaloid obtained from Huperzia saururus (Lam.) Trevis. (Lycopodiaceae). Its structure and relative stereochemistry were elucidated on the basis of its spectral data and chemical correlations. Additionally, acetylcholinesterase inhibitory activity was evaluated (IC50 = 209.6 ± 1.1 μM). The structure of the already identified alkaloid sauroxine was also re-validated through two dimensional NMR data.Keywords: Huperzia saururus; N-demethyl-sauroxine; acetylcholinesterase inhibition; sauroxine NMR two dimensional data.