SAUROINE, AN ALKALOID FROM HUPERZIA SAURURUS WITH ACTIVITY IN WISTAR RATS IN ELECTROPHYSIOLOGICAL AND BEHAVIORAL ASSAYS RELATED TO MEMORY RETENTION

VALLEJO, M.G.; ORTEGA, M.G.; CABRERA, J.L; CARLINI, V.P.; RUBIALES DE BARIOGLIO, S.; ALMIRÓN, R.S.; RAMÍREZ, O.A.; AGNESE, A.M.

Elsevier

Lugar: Irlanda; Año: 2009 vol. 72 p. 156 - 156

p class="MsoNormal" style="text-align: justify; line-height: 200%; text-indent: 36pt; margin: 0cm 0cm 0pt;">The present study intends to determine the effect of sauroine, the main alkaloid obtained from Huperzia saururus (Lam.) Trev. on memory retention and learning. To evaluate this, electrophysiological experiments and behavioral tests (step down) were performed. Results show that sauroine improves memory retention in the step-down test, significantly increasing hippocampal plasticity.