HUPERZIA SAURURUS INCREASES MEMORY RETENTION IN RATS.

M.G. VALLEJO; M.G. ORTEGA; J.L. CABRERA; V.P. CARLINI; S. RUBIALES DE BARIOGLIO; A. M. AGNESE

Elsevier

Lugar: Irlanda; Año: 2007 vol. 111 p. 685 - 685

p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: 200%; text-align: justify;">         Huperzia saururus is reported in Argentinean popular medicine as a memory improver. Chemical studies have shown that the main constituents of the species are Lycopodium alkaloids. On the basis of this information a purified alkaloid extract was obtained by alkaline extraction of the aerial parts. The aim of this work was to investigate the effects of intra – hippocampal administration of the purified alkaloid extract (AE) on memory retention in vivo, using a step down test, in order to correlate with previous results obtained in vitro in an electrophysiological model. The AE administratio