ADVANCES IN NATURAL EXTRACTS USED FOR ANTIBIOTIC RESISTANT BACTERIA TREATMENT: THE GRAM NEGATIVE CASES

QUINTERO CA; VALLEJO M; BONTTI S; PATIÑO S; PÉREZ GIRABEL R

Southern Journal of Sciences

Tchê Associated Editors

Año: 2022

2764-5967

ackground: Infectious diseases are a global problem, the second human death cause. Infectious diseases caused by pathogenic bacteria have been treated with a high degree of efficacy. However, even when the 20 century was considered the ?golden age? of antibiotics, bacteria developed a different resistance mechanism to antibiotics. . In 2017, the WHO issued an alert about 12 bacteria with an urgent need to develop new antibiotics. Aims: One strategy for discovering new anttibiotics is using natural extracts. The aim of this review is to analyze the current knowledge of their antibacterial activity against the pathogens listed by WHO, focusing in the Gram negative group. Methods: A systematic review of the literature in PubMed was performed to search for publications describing the use of natural extracts as antibiotics over bacteria. The exclusion criteria consisted of limiting papers on natural extracts tested over the bacteria culture related to eigth selected bacteria, according to