NATURAL EXTRACTS AS A PROMISING SOLUTION FOR GRAM-POSITIVE ANTIBIOTIC RESISTANCE: A COMPREHENSIVE REVIEW

VALLEJO M; BONTTI S; PATIÑO S; PÉREZ GIRABEL R; QUINTERO CA

Southern Journal of Sciences

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Año: 2023 vol. 31 p. 26 - 26

ackground: Antibiotic resistance is currently one of the biggest problems in public health. Infectious diseases are the second human death cause, and the emergence of antimicrobial-resistant bacteria increases mortality and morbidity rates. There is a growing clinical need for the development of new antibiotics. In this line, WHO issued an alert about 12 bacteria with an urgent need to develop new antibiotics. Aims: This review aims to analyze the current knowledge of their antibacterial activity against the gram-positive pathogens listed by WHO and their extraction techniques. Methods: We systematically reviewed the literature in PubMed, searching publications describing the use of natural extracts as antibiotics over bacteria. The exclusion criteria consisted of limiting papers on natural extracts tested over the bacteria culture related to eleven selected bacteria, according to an alert issued by WHO in 2017, and seven plant extracts. Results: All the gram-positive bacteria present