Alternative Method with Amperometric Detection for Ranitidine Determination

VALERIA PFAFFEN; PATRICIA INÉS ORTIZ

AMER CHEMICAL SOC

Año: 2010 vol. 49 p. 4026 - 4026

n alternative, simple, and reliable FIA amperometric method for ranitidine quantification was developed. A working glassy carbon electrode and a Ag|AgCl|NaCl (3 M) reference electrode were used. The determination is based on the electrochemical oxidation of ranitidine at 1.2 V in phosphate buffer solution (pH 7.2). The determination of ranitidine in the range of 1 × 10-6 to 2 × 10-5 M was possible with a sampling frequency of 120 h-1. The method was validated and satisfactorily applied to the determination of ranitidine in pharmaceutical formulations with a low limit of detection (6 × 10-7 M) and a quantitative recovery with no interferences from excipients. The results compare favorably with those obtained by the liquid chromatographic method of the U.S. Pharmacopoeia.