A systematic approach to the synthesis of LDH nanoparticles by response surface methodology

CECILIA VASTI; VALERIA PFAFFEN; ERNESTO AMBROGGIO; MAURICIO GALIANO; RICARDO ROJAS DELGADO; CARLA E. GIACOMELLI

APPLIED CLAY SCIENCE

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2017 vol. 137 p. 151 - 151

0169-1317

he customization of the properties of layered double hydroxides nanoparticles (LDH-NPs) is essential to optimizetheir design innovative systems for biomedical applications. Response surface methodologies (RSMs), a collectionof mathematical and statistical techniques that allows multivariate optimization of processes, are a usefultool for LDH-NPs customization. In this work, RSMs were used to study the synthesis parameters governing thesize and composition of Mg\\Al LDH-NPs (Mg/Al = 3) labeled with fluorescein isothiocyanate (FITC2−) and preparecustomized samples for biological assays. The influence of [Al3+], [OH−]/[Mg2++Al3+], 2[FITC2−]/[Al3+]and time of the hydrothermal treatment (tHT) was determined by a Box-Behnken experimental design (BBD).The experimental responses were hydrodynamic diameter (dH), polidispersity index (PI) and FITC2− content(%FITC), and their dependence with the synthesis variables was described by polynomial model. The model correlatedhi