PRENYLATED FLAVONOID 6PP SHOWS DUAL ACTION: ANTIFUNGAL EFFECT AND RHODAMINE 6G EFFLUX INHIBITION

PERALTA MARIANA A; CALISE MAXIMILIANO; ORTEGA, M. GABRIELA; CABRERA, JOSE L.; DIEZ, R.A.; PEREZ, CRISTINA

INST HISTOL EMBRIOL-CONICET

Año: 2009 vol. 33 p. 11 - 11

font size="2"> Some compounds of vegetal origin show antimicrobial synergism. When 2´,4´-dihydroxy-5´-(1´´´,1´´´-dimethylallyl)-6-prenyl-pinocembrin (6PP, isolated from roots of Dalea elegans) and fluconazole (Flz) were incorporated to the incubation medium, inhibited the efflux of rhodamine 6G (Rh 6G) in Candida albicans resistant to azoles (CaR). This strain, isolated from the oral cavity, was obtained from Dr. T.White (University of Washington, Seattle, EE.UU) and expresses transporters of CDR1, CDR2 and MDR1 type. Our parameters were for 6PP and Flz respectively, maximum inhibition: 45.46% and 41.42%; apparent KI