Antifungal activity of a prenylated flavonoid from Dalea elegans against Candida albicans biofilms

PERALTA MARIANA A; DA SILVA, MARIA ANGEL; ORTEGA, M. GABRIELA; CABRERA JOSE L.; PARAJE, MARÍA GABRIELA

ELSEVIER GMBH

Año: 2015 vol. 22 p. 975 - 975

div data-etype="ab" class="abstract svAbstract ">AbstractBackgroundThe continuing emergence of infections with antifungal resistant Candida strains requires a constant search for new antifungal drugs, with the plant kingdom being an important source of chemical structures.PurposeThe present study investigated the antifungal effect of 2′,4′-dihydroxy-5′-(1′′′,1′′′-dimethylallyl)-8-prenylpinocembrin (8PP, formerly 6PP), a natural prenylflavonoid, on Candida albicans biofilms, and compared this with an azole antifungal (fluconazole) by studying the cellular stress and antioxidant response.Study design/methodsThe fluconazole sensitive (SCa) and azole-resistant (RCa) C. albicans strains were used, with biofilm formation being studied