Neuroprotective effects of prenylated flavanones isolated from Dalea species, in vitro and in silico studies

SANTI, MARÍA D.; ARREDONDO, FLORENCIA; CARVALHO, DIEGO; ECHEVERRY, CAROLINA; PRUNELL, GISELLE; PERALTA, MARIANA A.; CABRERA, JOSÉ L.; ORTEGA, MARÍA G.; SAVIO, EDUARDO; ABIN-CARRIQUIRY, JUAN A.

EUROPEAN JOURNAL OF MEDICAL CHEMISTRY

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

Lugar: Paris; Año: 2020 vol. 206

0223-5234

eurodegenerative diseases (NDs) represent a global problem on public health, with a growing incidence as human longevity increases. Currently, although there are palliative strategies available for most of these diseases, there is a lack of effective therapies for their cure. Flavonoids are extensively studied for their multi-target behavior. Among numerous biological activities, it has been reported that they act at the CNS level, presenting neuroprotective activity through different mechanisms of action. Dalea L. (Fabaceae) is an American genus, with about 172 species. Dalea elegans Gillies ex. Hook. & Arn and Dalea pazensis Rusby, both South American species, are the important source of natural compounds of the prenylated flavanones type. In the present study, five prenylated flavanones isolated from Dalea species were assayed for their neuroprotective activity in two in vitro models of neurodegeneration. Flavanones 1 and 2 exhibited neuroprotective effects against oxidative stress