Buscador de Personas - SIGEVA - Universidad Nacional de Córdoba

taphylococcus aureus has become the most common opportunistic microorganism relatedto nosocomial infections due to the bacteria capacity to form biofilms on biomedical devicesand implants. Since bacterial adhesion is the first step in this pathogenesis, it is evident thatinhibiting such a process will reduce the opportunity for bacterial colonization on the devices.This work is aimed at optimizing a surface biofunctionalization strategy to inhibit the adhesionof S. aureus on solid substrates. The first part of the work deals with the albumin adsorptiondesorptionprocess, studied by a factorial design of experiments to explore a wide range ofexperimental factors (protein concentration, pH, flow rate and adsorption time) and responses(initial adsorption rate, adsorbed amount, desorbed extent) for hydrophilic and hydrophobicsubstrates, with a reduced number of experiments. This approach allows the simultaneousevaluation of the factors affecting the albumin adsorption-desorption process to

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