Ciprofloxacin-intercalated layered double hydroxide-in-hybrid films as composite dressings for controlled antimicrobial topical delivery

SALGUERO, YADIRA; VALENTI, LAURA; ROJAS, RICARDO; GARCÍA, MÓNICA C.

MATERIALS SCIENCE & ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS

ELSEVIER SCIENCE BV

Año: 2020 vol. 111

0928-4931

ilms based on biopolymers and loaded with antimicrobial agents are convenient pharmaceutical dosage formsfor topical application. Inorganic carriers loaded with these agents lead to composite materials, which combinedwith polymers produce further functionality. Here, hybrid composite films based on layered double hydroxide(LDH) and hyaluronan (HS) as ciprofloxacin (Cip) delivery systems were studied as an alternative for prophylaxis and treatment of opportunistic infections in wounds. Cip-intercalated Zn-Al LDH (LDH-Cip), with high drugloading and crystallinity, were obtained by a precipitation at variable pH method, and then included in a HSdispersion for obtaining the hybrid composite films by solvent casting. Physicochemical characterization of filmsshowed that a composite material where the HS acted as matrix and LDH-Cip aggregates acted as filler wereobtained. LDH-Cip were uniformly dispersed along the (LDH-Cip)/HS films, which exhibited roughness in theirsurface, increasing thei