Resumen:
he aim of this work was to study Rhamnus purshiana (Cáscara sagrada) extract spray-drying in order to obtain powders with good rheological properties for direct compression (DC) and stability attributes.
The experiments were carried out in a Büchi B-290 Mini Spray Dryer using colloidal silicon dioxide as carrier agent. A 25−1 fractional factorial statistical design was used to find adequate spray-drying operating
conditions to produce Cáscara sagrada powders with good flow, good compactability properties, high process yield, low moisture content, low hygroscopicity, and caking tendency. Morphology, size, structural and
thermal properties of the particles were also evaluated. The operating variables studied were air inlet temperature, atomization air flow rate, pump feed rate, aspiration capacity, and feed solids concentration.
The 25−1 factorial experimental design used was a good strategy to establish spray-drying operating conditions to produce Cáscara sagrada extrac